时间：2026-04-10
本文（Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels）原载Medicinal Research Reviews，由四川大学李国菠教授等科研人员创作，系四川智慧社会智能治理重点实验室智慧法治研究所的系列学术成果。本网站后续将持续分享实验室的系列学术成果，欢迎大家阅读。
Transient receptor potential canonical (TRPC) channels, a subfamily of calcium-permeable cation channels, regulate diverse physiological processes and are implicated in disorders including neurological conditions, cardiovascular diseases, and chronic kidney disease. Recent advances in cryo-electron microscopy (cryo-EM) have elucidated TRPC structures, while subtype-selective modulators have clarified their pathophysiological roles and therapeutic potential. This review integrates the structural and functional attributes of TRPC channels, emphasizing their contributions to health and disease. We highlight synthetic strategies and structure–activity relationships driving the development of selective pharmacological tools, several of which show preclinical promise. By uniting TRPC biology with medicinal chemistry, this study provides strategic guidance for advancing clinically viable TRPC-targeted therapeutics.
Qiao, X.; Ren, C.; Wang, W.; Wang, X.; Li, G.-B.; Chen, C.; Ye, B.; Zeng, X.; Xiao, Y.; Hong, X. Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels. Medicinal Research Reviews 2026, 46(1): 112-148.（论文下载）
