论文|Juntao Li, Xiangyu Zhang, Yi Ye, Xuewen Li, Yan Gu, Libing Yun：Awareness on tetrodotoxin of illegal activity：forensic issue from a rare homicide case report and literature review

本文（Awareness on tetrodotoxin of illegal activity：forensic issue from a rare homicide case report and literature review）原载Journal of Forensic and Legal Medicine，由四川大学华西基础医学院与法医学院云利兵副教授等科研人员创作，系四川大学智慧法治超前部署学科系列学术成果。后续会持续分享四川大学智慧法治超前部署学科系列学术成果，欢迎大家阅读。

Abstract:The authors describe an extremely rare case of homicide by injecting tetrodotoxin (TTX) as lethal neurotoxin found in puffer fish. After a thorough investigation, the male victim was found to have a broken stalk from syringe needle in the subcutaneous tissue of left buttock and severe asphyxia confirmed by the main pathological findings at autopsy. During tortuous toxicological analysis, TTX was revealed by ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) as well as acute intoxication confirmed from forensic examination. The literature of qualitative and quantitative determination of TTX from human fluids was also reviewed to expect widely acceptable detection strategies. This case highlighted the importance of TTX toxicant with chemical formula name purchased through e-commerce, so as to improve particular emphasis and supervision on harmful substances possibly using hidden information or illegal means. Histopathological and toxicological results demonstrated here provided a reference and other useful information to the challenges of forensic casework. In general, the case report illustrates medico-legal issues of more attention to the possibility of TTX poisoning in rapid death and the need of routine postmortem tox screening in future practice.

Juntao Li, Xiangyu Zhang, Yi Ye, Xuewen Li, Yan Gu, Libing Yun. Awareness on tetrodotoxin of illegal activity：forensic issue from a rare homicide case report and literature review, Journal of Forensic and Legal Medicine. 2021 Apr.（论文下载）